Added: Austine Ohalloran - Date: 19.10.2021 23:12 - Views: 41682 - Clicks: 720
The urines were coded, randomized, and analyzed under blind conditions. Following heroin administration, 6-AM was excreted rapidly with an average half-life of 0. This resulted in a very short detection time for 6-AM with a range of h at the most sensitive cutoff limit.
This short detection time limits the usefulness of 6-AM as a marker for identification of heroin abusers to a period immediately after drug use. In contrast, free morphine and total morphine were detectable up to approximately 24 h after heroin administration. The average half-life for free morphine was 3. It is concluded that the presence of 6-AM in urine can be interpreted with confidence to mean that heroin, or 6-AM, was administered within 24 h of specimen collection and that the presence of 6-AM in urine is not caused by morphine or codeine administration.
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Optional text in :. Save Cancel. Create a file for external citation management software Create file Cancel. of items displayed: 5 10 15 20 50 Create RSS Cancel. RSS Link Copy. Full text links Cite Display options Display options. Holler JM, et al. J Anal Toxicol. PMID: Urinary excretion profiles for total morphine, free morphine, and 6-acetylmorphine following smoked and intravenous heroin. Smith ML, et al.
Forensic drug testing for opiates. Urinary excretion profile of intranasal snorted heroin. Cone EJ, et al. Rivier L, et al. Schweiz Rundsch Med Prax. PMID: Review. Detection time of drugs of abuse in urine. Vandevenne M, et al. Acta Clin Belg. See all similar articles. Foppe KS, et al. Epub May Jakobsson G, et al. Wastewater-based epidemiology pilot study to examine drug use in the Western United States.
Bishop N, et al. Sci Total Environ. Epub Jul Costa C, et al. Kalinowski T, et al. J Hazard Mater. Epub Dec See all "Cited by" articles. Publication types Clinical Trial Actions. Randomized Controlled Trial Actions. Half-Life Actions. Humans Actions. Male Actions. Molecular Structure Actions. Random Allocation Actions. Reproducibility of Actions. Time Factors Actions. Substances Morphine Derivatives Actions. Heroin Actions. Morphine Actions. Full text links [x] Silverchair Information Systems.
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Forensic drug testing for opiates: I. Detection of 6-acetylmorphine in urine as an indicator of recent heroin exposure; drug and assay considerations and detection times