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Background: Gabapentin is active in the regulation of facilitated pain states evoked by tissue injury. The mechanism of this action is believed to be through a specific binding site, likely at the spinal level. Nonsteroidal antiinflammatory drugs have a comparable behavioral profile, although their actions are believed to be mediated by cyclooxygenase inhibition at the spinal level. This study was undertaken to determine the nature of the interaction of these two mechanistically distinct antihyperalgesic agents in rats in a model of facilitated processing, the formalin test. Their interaction was characterized using an isobolographic analysis.
: Injection of formalin into the hind paw caused a biphasic flinching and parallel increases in MABP. Gabapentin similarly showed a dose-dependent suppression of the MABP and heart rate response only during phase 2; ibuprofen showed dose-dependent reduction of MABP response in both phases. The isobolographic analysis carried out using equipotent dose ratios in phase 2 revealed an additive interaction between the two drugs.
Neither gabapentin nor ibuprofen affected the baseline cardiovascular measures. Conclusion: Gabapentin and ibuprofen independently alter the facilitated state as measured by somatomotor and autonomic response. Together these agents interact in an additive fashion if delivered concurrently. This combination may prove useful in managing postinjury pain states in humans. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable.
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RSS Link Copy. Full text links Cite Display options Display options. Abstract Background: Gabapentin is active in the regulation of facilitated pain states evoked by tissue injury. Similar articles Characteristic of interactions between intrathecal gabapentin and either clonidine or neostigmine in the formalin test. Yoon MH, et al.
Anesth Analg. PMID: The interaction between gabapentin and amitriptyline in the rat formalin test after systemic administration. Heughan CE, Sawynok J. Heughan CE, et al. Analysis of interactions between serotonin and gabapentin or adenosine in the spinal cord of rats. Epub Dec Gabapentin prevents hyperalgesia during the formalin test in diabetic rats. Neurosci Lett. The effect of intrathecal gabapentin on pain behavior and hemodynamics on the formalin test in the rat.
See all similar articles. Hartrick CT, et al. J Pain Res. Gabapentin-induced drug-seeking-like behavior: a potential role for the dopaminergic system. Althobaiti YS, et al. Sci Rep. Meleine M, et al. World J Gastroenterol. Synergistic anti-allodynic effect between intraperitoneal thalidomide and morphine on rat spinal nerve ligation-induced neuropathic pain. Lee HG, et al.
Korean J Anesthesiol. Epub Oct Semi-mechanistic modelling of the analgesic effect of gabapentin in the formalin-induced rat model of experimental pain. Taneja A, et al. Pharm Res. Epub Oct 5. See all "Cited by" articles. Publication types Research Support, Non-U. Gov't Actions. Research Support, U. Gov't, P. Animals Actions. Disease Models, Animal Actions. Dose-Response Relationship, Drug Actions. Drug Synergism Actions. Gabapentin Actions. Injections, Intraperitoneal Actions. Male Actions. Rats Actions. Rats, Sprague-Dawley Actions. Substances Acetates Actions.
Amines Actions. Analgesics Actions. Analgesics, Non-Narcotic Actions. Cyclohexanecarboxylic Acids Actions. Ibuprofen Actions. Full text links [x] Silverchair Information Systems. Copy Download.Can i take painkillers with gabapentin
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Can I Take Other Medications With Gabapentin?